Antimicrobial Activity of Cox-2 Inhibitor
نویسندگان
چکیده
The present study was undertaken to evaluate the antimicrobial activity of Etoricoxib. At various concentrations, ranging from 20-100 μg/ml, Etoricoxib exhibits zone of inhibition of 6.5, 7, 8 and 13 respectively against p. aeruginosa while, it showed zone of inhibition of 10, 15, 18 against S. aureus and 8, 15 21 against E.coli at the concentration range of 25-100 μg/ml. It showed more activity against S. aureus, followed by E. coli, Pseudomonas, and least activity against C.albicans and S.typhi. The MIC of the etoricoxib were ranged between 100 to 200 μg/ml. The MIC values of the three test pathogens S. aureus, E. coli, Pseudomonas were found to have MIC of 100 μg/ml, 150 μg/ml and 200 μg/ml respectively. The results indicate that Etoricoxib exhibit the antimicrobial activity compared to Doxorubicin and Ketoconazole.
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